Infantile onset panniculitis with uveitis and systemic granulomatosis (IOPUG) is a rare, chronic, inflammatory disorder that affects the skin, eyes, and other organs. It is characterized by recurrent episodes of inflammation of the fat layer under the skin (panniculitis), inflammation of the uvea (uveitis), and systemic granulomatous inflammation. Symptoms may include skin rashes, eye redness and pain, joint pain, fever, and fatigue. Treatment typically involves a combination of topical and systemic medications, such as corticosteroids, immunosuppressants, and biologics.

The symptoms of Infantile onset panniculitis with uveitis and systemic granulomatosis can vary depending on the individual, but may include:

-Fever
-Rash
-Joint pain
-Eye inflammation
-Swollen lymph nodes
-Weight loss
-Fatigue
-Abdominal pain
-Diarrhea
-Liver and spleen enlargement
-Anemia
-Blood clots
-Skin nodules
-Granulomas in the lungs, liver, and other organs

The exact cause of Infantile onset panniculitis with uveitis and systemic granulomatosis is unknown. However, it is believed to be an autoimmune disorder, where the body's immune system mistakenly attacks healthy tissue. It is also thought to be triggered by an infection or an environmental factor. Other possible causes include genetic factors, certain medications, and certain underlying medical conditions.

1. Corticosteroids: Corticosteroids are the mainstay of treatment for infantile onset panniculitis with uveitis and systemic granulomatosis. These medications reduce inflammation and can help to control the symptoms of the condition.

2. Immunosuppressants: Immunosuppressants such as methotrexate, azathioprine, and cyclosporine can be used to help control the inflammation associated with infantile onset panniculitis with uveitis and systemic granulomatosis.

3. Biologic agents: Biologic agents such as infliximab and adalimumab can be used to help control the inflammation associated with infantile onset panniculitis with uveitis and systemic granulomatosis.

4. Phototherapy:

1. Genetic predisposition: Infantile onset panniculitis with uveitis and systemic granulomatosis is thought to have a genetic component, as it is more common in certain families.

2. Immune system dysfunction: Infantile onset panniculitis with uveitis and systemic granulomatosis is thought to be caused by an abnormal immune system response.

3. Environmental factors: Exposure to certain environmental factors, such as certain medications, infections, or toxins, may increase the risk of developing infantile onset panniculitis with uveitis and systemic granulomatosis.

4. Age: Infantile onset panniculitis with uveitis and systemic granulomatosis is most common in infants and young children.

Unfortunately, there is no known cure for Infantile onset panniculitis with uveitis and systemic granulomatosis. Treatment typically involves medications to reduce inflammation and suppress the immune system, such as corticosteroids, methotrexate, and cyclosporine. Other medications, such as antibiotics, may also be prescribed to treat any underlying infections.