About Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance

What is Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance is a rare form of nephrotic syndrome, a kidney disorder that causes the body to excrete too much protein in the urine. It is characterized by an initial response to steroid treatment, followed by a relapse of the disease despite continued steroid treatment. The cause of this condition is unknown, but it is thought to be an autoimmune disorder. Treatment typically involves a combination of steroids and other immunosuppressive medications.

What are the symptoms of Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

The most common symptoms of Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance include:

- Swelling of the face, hands, feet, and abdomen

- High blood pressure

- Proteinuria (excess protein in the urine)

- Foamy urine

- Fatigue

- Weight gain

- Loss of appetite

- Nausea

- Vomiting

- Itching

- Darkening of the skin

- Increased risk of infection

- Increased risk of blood clots

- Increased risk of kidney failure

What are the causes of Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

The exact cause of idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance is unknown. However, it is believed to be related to genetic and environmental factors. Possible causes include:

• Genetic mutations that affect the structure and function of the kidney

• Exposure to certain medications or toxins
• Immune system disorders
• Viral infections
• Autoimmune diseases
• Abnormalities in the structure of the kidney

What are the treatments for Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

1. ACE inhibitors or angiotensin receptor blockers (ARBs): These medications help reduce proteinuria and slow the progression of kidney damage.

2. Immunosuppressive agents: These medications, such as cyclophosphamide, mycophenolate mofetil, and tacrolimus, help reduce inflammation and suppress the immune system.

3. Corticosteroids: These medications, such as prednisone, help reduce inflammation and proteinuria.

4. Diuretics: These medications, such as furosemide, help reduce fluid retention and swelling.

5. Plasma exchange: This procedure helps remove antibodies from the blood that can cause inflammation and damage to the kidneys.

6. Rituximab: This medication helps reduce inflammation and proteinuria.

7. Other medications:

What are the risk factors for Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

1. Age: Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance is more common in children under the age of 5.

2. Gender: Boys are more likely to develop this condition than girls.

3. Ethnicity: African-American and Asian children are more likely to develop this condition than Caucasian children.

4. Family history: Having a family member with this condition increases the risk of developing it.

5. Infections: Certain infections, such as viral infections, can increase the risk of developing this condition.

6. Exposure to certain medications: Certain medications, such as non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics, can increase the risk of developing this condition.

Is there a cure/medications for Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance?

Yes, there are medications and treatments available for idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance. Treatment options include corticosteroids, calcineurin inhibitors, immunosuppressants, and other medications. Additionally, lifestyle modifications such as dietary changes, exercise, and stress management can help manage symptoms.