Hereditary sensory and autonomic neuropathy type 1B (HSAN1B) is a rare inherited disorder that affects the peripheral nervous system. It is characterized by the progressive loss of sensation in the hands and feet, as well as autonomic dysfunction, which can lead to problems with sweating, blood pressure, and heart rate. Other symptoms may include muscle weakness, joint pain, and difficulty walking. HSAN1B is caused by mutations in the NTRK1 gene and is inherited in an autosomal dominant manner. Treatment is supportive and may include physical therapy, medications, and lifestyle modifications.

The symptoms of Hereditary sensory and autonomic neuropathy type 1B vary from person to person, but may include:

- Loss of sensation in the hands and feet
- Loss of reflexes
- Muscle weakness
- Loss of coordination
- Abnormal sweating
- Abnormal blood pressure
- Abnormal heart rate
- Abnormal digestion
- Abnormal bladder and bowel function
- Difficulty walking
- Painful sensations in the hands and feet
- Numbness in the hands and feet
- Burning or Tingling sensations in the hands and feet
- Loss of sensation in the face
- Loss of sensation in the tongue
- Difficulty speaking
- Difficulty swallowing
- Vision problems
- Hearing problems
- Balance problems
- Cognitive problems

Hereditary sensory and autonomic neuropathy type 1B (HSAN1B) is caused by mutations in the NTRK1 gene. This gene provides instructions for making a protein called neurotrophic tyrosine kinase receptor type 1 (TrkA). This protein is involved in the development and maintenance of nerve cells, and mutations in the NTRK1 gene can lead to the death of these cells. This can cause the symptoms of HSAN1B, including decreased sensation in the hands and feet, decreased sweating, and impaired balance.

1. Pain management: Pain management is an important part of treating HSAN1B. This may include medications such as non-steroidal anti-inflammatory drugs (NSAIDs), opioids, anticonvulsants, and tricyclic antidepressants.

2. Physical therapy: Physical therapy can help improve strength, balance, and coordination.

3. Occupational therapy: Occupational therapy can help with activities of daily living, such as dressing, bathing, and eating.

4. Surgery: Surgery may be necessary to correct deformities or to relieve pressure on nerves.

5. Assistive devices: Assistive devices, such as braces, canes, and wheelchairs, can help with mobility.

6. Nutritional support: Nutritional support may be necessary to maintain adequate nutrition.

7. Genetic counseling: Genetic

1. Autosomal dominant inheritance
2. Mutations in the NTRK1 gene
3. Family history of HSAN1B
4. Age of onset before 10 years
5. Progression of symptoms over time
6. Loss of sensation in the feet and hands
7. Loss of reflexes in the feet and hands
8. Muscle weakness
9. Abnormal gait
10. Difficulty with balance
11. Loss of autonomic functions such as sweating, blood pressure regulation, and bladder control

There is no cure for Hereditary sensory and autonomic neuropathy type 1B, but medications can be used to help manage symptoms. These medications may include anticonvulsants, antidepressants, and pain relievers. Physical therapy and occupational therapy may also be recommended to help manage symptoms.