Hereditary persistence of alpha-fetoprotein (HPAFP) is a rare genetic disorder in which the body produces abnormally high levels of alpha-fetoprotein (AFP). AFP is a protein normally produced by the fetus during pregnancy and is normally found in the mother's blood. In HPAFP, the body continues to produce AFP after birth, leading to elevated levels in the blood. Symptoms of HPAFP can include jaundice, enlarged liver, and delayed development. Treatment typically involves monitoring of AFP levels and managing any associated symptoms.

The most common symptom of Hereditary Persistence of Alpha-Fetoprotein (HP-AFP) is elevated levels of alpha-fetoprotein (AFP) in the blood. Other symptoms may include:

- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Weight loss
- Weakness
- Fatigue
- Jaundice
- Dark urine
- Itching
- Swelling of the abdomen
- Abnormal liver function tests
- Abnormal kidney function tests
- Abnormal blood clotting tests
- Abnormal cholesterol levels

The causes of Hereditary Persistence of Alpha-Fetoprotein (HP-AFP) are not fully understood. It is believed to be caused by a genetic mutation that affects the production of AFP, a protein produced by the liver. This mutation can be inherited from either parent, and is more common in certain ethnic groups. Other possible causes include environmental factors, such as exposure to certain chemicals or radiation.

1. Surgery: Surgery is the most common treatment for Hereditary Persistence of Alpha-Fetoprotein (HPAP). This involves removing the affected part of the liver, which is usually the left lobe.

2. Medication: Medications such as diuretics, beta-blockers, and ACE inhibitors may be prescribed to help reduce the amount of AFP in the blood.

3. Diet: A low-fat, low-sodium diet may be recommended to help reduce the amount of AFP in the blood.

4. Lifestyle Changes: Regular exercise and stress reduction techniques may be recommended to help reduce the amount of AFP in the blood.

5. Genetic Counseling: Genetic counseling may be recommended to help individuals and families understand the risks associated with HPAP and to provide support and resources.

1. Family history of Hereditary Persistence of Alpha-Fetoprotein (HP-AFP)
2. Genetic mutations in the AFP gene
3. Exposure to certain environmental toxins
4. Maternal diabetes
5. Maternal obesity
6. Maternal smoking
7. Maternal alcohol consumption
8. Advanced maternal age
9. Low birth weight
10. Premature birth

At this time, there is no cure or medications for Hereditary Persistence of Alpha-Fetoprotein (HP-AFP). However, there are treatments available to manage the symptoms associated with HP-AFP. These treatments may include dietary modifications, lifestyle changes, and regular monitoring of AFP levels. Additionally, genetic counseling may be recommended to help individuals and families understand the condition and its implications.