Hereditary motor and sensory neuropathy type 5 (HMSN5) is a rare inherited disorder that affects the peripheral nervous system. It is characterized by progressive weakness and wasting of the muscles, sensory loss, and autonomic dysfunction. Symptoms usually begin in childhood and can include muscle weakness, numbness and tingling in the hands and feet, difficulty walking, and bladder and bowel problems.

Symptoms of Hereditary Motor and Sensory Neuropathy Type 5 (HMSN5) can vary from person to person, but may include:

- Muscle Weakness and wasting
- Loss of sensation in the hands and feet
- Painful muscle cramps
- Loss of reflexes
- Difficulty walking
- Balance problems
- Difficulty with fine motor skills
- Difficulty with speech
- Difficulty swallowing
- Abnormal gait
- Fatigue
- Difficulty with bladder and bowel control

Hereditary motor and sensory neuropathy type 5 (HMSN5) is caused by mutations in the SH3TC2 gene. This gene provides instructions for making a protein that is involved in the development and maintenance of the peripheral nervous system, which is made up of the nerves that connect the brain and spinal cord to the rest of the body. Mutations in the SH3TC2 gene lead to the production of an abnormally short, nonfunctional version of the protein, which disrupts the development and maintenance of the peripheral nervous system. This disruption leads to the signs and symptoms of HMSN5.

1. Pain management: Pain medications, such as non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and anticonvulsants, can help manage the pain associated with HMSN type 5.

2. Physical therapy: Physical therapy can help improve muscle strength and coordination, as well as reduce pain.

3. Occupational therapy: Occupational therapy can help with activities of daily living, such as dressing, bathing, and eating.

4. Assistive devices: Assistive devices, such as wheelchairs, walkers, and braces, can help with mobility.

5. Surgery: Surgery may be recommended to correct any deformities or to release pressure on nerves.

6. Gene therapy: Gene therapy is a new and experimental treatment for HMSN type 5. It involves introducing a healthy gene into the body

1. Family history of Hereditary motor and sensory neuropathy type 5
2. Age (most commonly affects adults between the ages of 30 and 50)
3. Gender (more common in males)
4. Ethnicity (more common in people of Mediterranean, Middle Eastern, and North African descent)
5. Exposure to toxins or certain medications
6. Vitamin B12 deficiency
7. Alcoholism
8. Diabetes
9. Autoimmune diseases
10. Infections (such as HIV, Lyme disease, and Epstein-Barr virus)

There is no cure for Hereditary motor and sensory neuropathy type 5, but medications can be used to help manage symptoms. These medications may include anticonvulsants, antidepressants, and muscle relaxants. Physical therapy and occupational therapy can also help to improve muscle strength and coordination.