Hemihyperplasia-multiple lipomatosis syndrome (also known as HMLS) is a rare genetic disorder characterized by asymmetrical overgrowth of one side of the body, multiple lipomas (benign fatty tumors), and other physical abnormalities. It is caused by a mutation in the PIK3CA gene. Symptoms may include asymmetrical body growth, multiple lipomas, facial abnormalities, and skeletal abnormalities. Treatment typically involves surgery to remove the lipomas and other physical abnormalities.

The symptoms of Hemihyperplasia-multiple lipomatosis syndrome vary from person to person, but may include:

-Uneven growth of one side of the body (hemihyperplasia)
-Uneven growth of the head, face, and limbs
-Abnormal fat deposits (lipomas)
-Abnormalities of the spine
-Abnormalities of the heart and blood vessels
-Abnormalities of the kidneys and urinary tract
-Abnormalities of the eyes
-Abnormalities of the skin
-Abnormalities of the nervous system
-Developmental delays
-Intellectual disability
-Seizures
-Hearing loss
-Speech delays

Hemihyperplasia-multiple lipomatosis syndrome is a rare genetic disorder caused by a mutation in the PIK3CA gene. This gene is responsible for producing an enzyme called phosphatidylinositol 3-kinase (PI3K), which is involved in cell growth and development. Mutations in this gene can lead to abnormal cell growth and development, resulting in the symptoms associated with Hemihyperplasia-multiple lipomatosis syndrome.

There is no known cure for Hemihyperplasia-multiple lipomatosis syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, speech therapy, and orthopedic surgery. Other treatments may include medications to reduce pain, swelling, and inflammation, as well as lifestyle modifications to reduce the risk of complications.

1. Genetic mutation: Hemihyperplasia-multiple lipomatosis syndrome is caused by a mutation in the PIK3CA gene.

2. Family history: Individuals with a family history of the condition are at an increased risk of developing the syndrome.

3. Age: The syndrome is more common in children and young adults.

4. Gender: Hemihyperplasia-multiple lipomatosis syndrome is more common in males than females.

At this time, there is no known cure for Hemihyperplasia-multiple lipomatosis syndrome. However, there are medications that can be used to manage the symptoms associated with the condition. These medications include pain relievers, anti-inflammatory drugs, and muscle relaxants. Additionally, physical therapy and occupational therapy may be recommended to help improve mobility and reduce pain.