Gingival fibromatosis-hypertrichosis syndrome is a rare genetic disorder characterized by excessive growth of the gums (gingival fibromatosis) and excessive hair growth (hypertrichosis). It is caused by a mutation in the FGFR1 gene. Symptoms may include thickening of the gums, excessive hair growth on the face, neck, and body, and dental problems such as overcrowding and malocclusion. Treatment may include surgery to remove the excess gum tissue and laser hair removal to reduce the excessive hair growth.

The main symptoms of Gingival fibromatosis-hypertrichosis syndrome are:

1. Excessive gum tissue growth (gingival fibromatosis)
2. Excessive hair growth (hypertrichosis)
3. Abnormal facial features, including a broad forehead, wide-set eyes, and a short nose
4. Abnormalities of the teeth, including delayed eruption, malocclusion, and enamel hypoplasia
5. Abnormalities of the hands and feet, including syndactyly (webbed fingers and toes) and polydactyly (extra fingers and toes)
6. Intellectual disability
7. Abnormalities of the heart, including ventricular septal defect and patent ductus arteriosus
8. Abnormalities of the kidneys, including renal cysts and

Gingival fibromatosis-hypertrichosis syndrome is a rare genetic disorder caused by mutations in the gene encoding the enzyme lysyl oxidase-like 1 (LOXL1). Mutations in this gene can lead to abnormal collagen production, which can cause the gums to become thick and overgrown. In addition, mutations in this gene can also lead to excessive hair growth, which is why this disorder is sometimes referred to as hypertrichosis.

1. Regular dental hygiene: Regular brushing and flossing of the teeth is essential to maintain good oral health and reduce the risk of gum disease.

2. Surgery: Surgery may be necessary to remove excess gum tissue and reduce the size of the gums.

3. Medications: Certain medications, such as antibiotics, may be prescribed to reduce inflammation and infection.

4. Laser therapy: Laser therapy may be used to reduce the size of the gums and reduce the amount of excess tissue.

5. Hormone therapy: Hormone therapy may be used to reduce the amount of excess hair growth.

6. Dietary changes: Eating a healthy diet and avoiding certain foods may help reduce inflammation and improve overall health.

1. Genetic predisposition: Gingival fibromatosis-hypertrichosis syndrome is an inherited disorder caused by a mutation in the FGFR2 gene.

2. Age: The condition is usually diagnosed in childhood or adolescence.

3. Gender: The condition is more common in males than females.

4. Ethnicity: The condition is more common in individuals of African descent.

There is no known cure for Gingival fibromatosis-hypertrichosis syndrome. Treatment is focused on managing the symptoms and preventing further complications. Medications such as antibiotics, antifungals, and anti-inflammatory drugs may be prescribed to reduce inflammation and infection. Surgery may be recommended to remove excess tissue or to improve the appearance of the gums.