Fukutin-related limb-girdle muscular dystrophy R13 (FLGMD R13) is a rare, inherited neuromuscular disorder caused by mutations in the FKTN gene. It is characterized by progressive muscle weakness and wasting, especially in the muscles of the hips, shoulders, and upper arms. Other symptoms may include joint contractures, scoliosis, and difficulty walking. There is currently no cure for FLGMD R13, but physical therapy, occupational therapy, and supportive care can help manage symptoms.

The symptoms of Fukutin-related limb-girdle muscular dystrophy R13 can vary from person to person, but generally include:

-Muscle Weakness and wasting, especially in the hips, shoulders, and upper arms
-Difficulty walking, running, and climbing stairs
-Difficulty lifting objects
-Joint contractures
-Scoliosis
-Cardiomyopathy
-Gastrointestinal problems
-Respiratory problems
-Cognitive and behavioral problems
-Seizures
-Vision and hearing problems

Fukutin-related limb-girdle muscular dystrophy (LGMD2I) is caused by mutations in the FKTN gene. These mutations lead to a deficiency of the protein fukutin, which is essential for the proper development of muscle fibers. This deficiency results in progressive muscle weakness and wasting, as well as other symptoms.

1. Physical therapy: Physical therapy can help improve strength, flexibility, and range of motion.

2. Occupational therapy: Occupational therapy can help with activities of daily living, such as dressing, bathing, and eating.

3. Assistive devices: Assistive devices, such as wheelchairs, walkers, and braces, can help with mobility.

4. Medications: Medications, such as corticosteroids, can help reduce inflammation and improve muscle strength.

5. Surgery: Surgery may be recommended to correct joint deformities or to improve mobility.

6. Genetic counseling: Genetic counseling can help families understand the condition and make informed decisions about their care.

1. Genetic mutation in the fukutin gene
2. Family history of Fukutin-related limb-girdle muscular dystrophy
3. Male gender
4. Age of onset (usually between 2 and 4 years old)
5. Ethnicity (more common in Japanese and Korean populations)
6. Weakness in the lower limbs
7. Difficulty walking
8. Muscle wasting
9. Joint contractures
10. Cardiomyopathy
11. Respiratory problems
12. Intellectual disability
13. Cataracts

At this time, there is no cure for Fukutin-related limb-girdle muscular dystrophy R13. However, there are medications that can help manage the symptoms of the condition. These include medications to help with muscle weakness, such as corticosteroids, and medications to help with pain, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Physical therapy and occupational therapy can also help to improve muscle strength and function.