Familial progressive hyperpigmentation is a rare genetic disorder characterized by the gradual darkening of the skin. It is caused by a mutation in the SLC45A2 gene, which is responsible for the production of melanin, the pigment that gives skin its color. Symptoms typically begin in childhood and worsen over time, resulting in dark patches on the skin that may be symmetrical or asymmetrical. Treatment is typically focused on managing the symptoms, such as using sunscreen and avoiding sun exposure.

The main symptom of Familial progressive hyperpigmentation is the development of dark patches on the skin. These patches may be symmetrical and can appear on the face, neck, chest, arms, and legs. Other symptoms may include:

• Itching or Burning sensation in the affected areas

• Discoloration of the skin

• Thickening of the skin

• Dryness of the skin

• Increased sensitivity to sunlight

• Scarring of the skin

• Hyperpigmentation of the nails

Familial progressive hyperpigmentation is a rare genetic disorder caused by mutations in the SLC45A2 gene. This gene is responsible for producing a protein that helps regulate the production of melanin, the pigment that gives skin its color. Mutations in this gene can cause an overproduction of melanin, resulting in dark patches of skin. Other causes of familial progressive hyperpigmentation include exposure to certain chemicals, such as hydroquinone, and certain medications, such as phenothiazines.

1. Topical corticosteroids: These medications can help reduce inflammation and reduce the appearance of hyperpigmentation.

2. Retinoids: Retinoids are vitamin A derivatives that can help reduce the appearance of hyperpigmentation.

3. Chemical peels: Chemical peels can help reduce the appearance of hyperpigmentation by removing the top layer of skin.

4. Laser treatments: Laser treatments can help reduce the appearance of hyperpigmentation by targeting the melanin in the skin.

5. Sun protection: Sun protection is essential for reducing the appearance of hyperpigmentation. Sunscreen, hats, and clothing can help protect the skin from further damage.

The risk factors for Familial progressive hyperpigmentation include:

1. Family history of the condition
2. Being of Asian or African descent
3. Exposure to ultraviolet radiation
4. Certain medications, such as phenytoin and minocycline
5. Certain medical conditions, such as Addison’s disease and diabetes
6. Certain skin conditions, such as eczema and psoriasis

There is no known cure for Familial progressive hyperpigmentation. Treatment options include topical creams and ointments, laser treatments, and phototherapy. Your doctor may also recommend lifestyle changes such as avoiding sun exposure and using sunscreen.