Familial mesial temporal lobe epilepsy with febrile seizures (FMTLE-FS) is a rare genetic disorder characterized by recurrent seizures that begin in the mesial temporal lobe of the brain and are associated with fever. It is caused by a mutation in the GRIN2A gene, which is responsible for the production of a protein involved in the transmission of electrical signals in the brain. Symptoms of FMTLE-FS include recurrent seizures, fever, and cognitive and behavioral problems. Treatment typically involves anticonvulsant medications and lifestyle modifications.

The symptoms of Familial mesial temporal lobe epilepsy with febrile Seizures can vary from person to person, but typically include:

-Recurrent seizures, usually beginning in childhood
-Fever-related Seizures (febrile seizures)
-Partial seizures, which may include sensory, motor, or autonomic symptoms
-Memory problems
-Behavioral changes
-Personality changes
-Depression
-Anxiety
-Sleep disturbances
-Difficulty concentrating
-Difficulty with language and communication

The exact cause of Familial mesial temporal lobe epilepsy with febrile seizures is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in certain genes that are involved in the regulation of brain activity. Environmental factors may include exposure to certain infections, such as the measles virus, or to certain toxins.

1. Medication: Antiepileptic drugs such as valproic acid, lamotrigine, levetiracetam, and topiramate are commonly used to treat familial mesial temporal lobe epilepsy with febrile seizures.

2. Surgery: In some cases, surgery may be recommended to remove the affected part of the brain.

3. Dietary Therapy: A ketogenic diet, which is high in fat and low in carbohydrates, may be recommended to help reduce the frequency and severity of seizures.

4. Complementary and Alternative Therapies: Complementary and alternative therapies such as acupuncture, massage, and yoga may be recommended to help reduce stress and improve overall health.

1. Family history of epilepsy
2. Genetic mutations
3. Febrile seizures
4. Age of onset (usually before age 6)
5. Gender (more common in males)
6. Abnormal EEG findings
7. Abnormal brain imaging findings
8. Abnormal neurological examination findings
9. Developmental delay
10. Cognitive impairment

There is no cure for Familial Mesial Temporal Lobe Epilepsy with Febrile Seizures (FMTLE-FS). However, medications can be used to help control the seizures. Commonly prescribed medications include anticonvulsants such as valproic acid, lamotrigine, levetiracetam, and topiramate. Other medications such as benzodiazepines and barbiturates may also be used to help control seizures. Additionally, lifestyle modifications such as avoiding triggers, getting adequate sleep, and avoiding stress can help reduce the frequency and severity of seizures.