Familial hyperaldosteronism type III (FH-III) is a rare inherited disorder caused by a mutation in the HSD3B2 gene. It is characterized by excessive production of aldosterone, a hormone that helps regulate salt and water balance in the body. Symptoms of FH-III include high blood pressure, low potassium levels, and excessive thirst and urination. Treatment typically involves medications to control blood pressure and potassium levels, as well as lifestyle changes.

The symptoms of Familial Hyperaldosteronism Type III (FH-III) vary depending on the severity of the condition. Common symptoms include:

-High blood pressure
-Headaches
-Fatigue
-Muscle weakness
-Muscle cramps
-Excessive thirst
-Frequent urination
-Salt cravings
-Weight loss
-Low potassium levels
-Abdominal pain
-Nausea and vomiting
-Loss of appetite
-Confusion
-Depression
-Irritability
-Anxiety

Familial hyperaldosteronism type III is caused by a mutation in the KCNJ5 gene, which is responsible for producing a protein called GIRK4. This protein is involved in the regulation of potassium levels in the body. Mutations in this gene can lead to an overproduction of aldosterone, a hormone that helps regulate blood pressure and electrolyte balance.

1. Dietary modifications: A low-sodium diet is recommended to reduce the amount of sodium in the body and reduce the symptoms of Familial Hyperaldosteronism Type III.

2. Medications: Diuretics, such as spironolactone, can be used to reduce the amount of sodium and water in the body.

3. Surgery: Surgery may be recommended to remove the affected adrenal gland.

4. Lifestyle changes: Regular exercise and stress management techniques can help reduce the symptoms of Familial Hyperaldosteronism Type III.

1. Family history of Familial Hyperaldosteronism type III
2. Genetic mutations in the HSD11B2 gene
3. High levels of aldosterone in the blood
4. Low levels of potassium in the blood
5. High blood pressure
6. Abnormal heart rhythms
7. Muscle weakness
8. Fatigue
9. Headaches
10. Nausea
11. Vomiting
12. Loss of appetite
13. Weight loss
14. Excessive thirst
15. Excessive urination

At this time, there is no known cure for Familial Hyperaldosteronism Type III. However, medications such as spironolactone, eplerenone, and amiloride can be used to help manage the symptoms of the condition. Additionally, lifestyle changes such as reducing salt intake and increasing potassium intake can help to reduce the symptoms of the condition.