Familial clubfoot due to 17q23.1q23.2 microduplication is a rare genetic disorder caused by a duplication of a small section of genetic material on chromosome 17. This duplication results in a range of physical and developmental abnormalities, including clubfoot, which is a deformity of the foot in which the heel is turned inward and the front of the foot is twisted outward. Other symptoms may include intellectual disability, delayed motor development, and speech and language delays.

The most common symptom of Familial clubfoot due to 17q23.1q23.2 microduplication is congenital clubfoot, which is a deformity of the foot that causes the heel and forefoot to turn inward. Other symptoms may include:

-Low muscle tone
-Abnormal gait
-Flat feet
-Abnormal toe position
-Pain in the feet
-Difficulty walking
-Joint stiffness
-Abnormal foot shape
-Abnormal foot size
-Abnormal foot arch

Familial clubfoot due to 17q23.1q23.2 microduplication is caused by a genetic mutation in the 17q23.1q23.2 region of the genome. This mutation causes an extra copy of the genes in this region, which can lead to the development of clubfoot. The exact mechanism of how this mutation causes clubfoot is not yet known, but it is thought to be related to the abnormal expression of certain genes in this region.

1. Physical therapy: Physical therapy is the mainstay of treatment for familial clubfoot due to 17q23.1q23.2 microduplication. Physical therapy can help to improve range of motion, strength, and flexibility in the affected foot.

2. Casting: Casting is often used to help correct the deformity of the foot. The cast is typically changed every two weeks until the desired position is achieved.

3. Surgery: Surgery may be necessary to correct the deformity if physical therapy and casting are not successful. Surgery may involve releasing the tight tendons and ligaments, or repositioning the bones of the foot.

4. Bracing: Bracing may be used to help maintain the corrected position of the foot after surgery.

1. A family history of clubfoot
2. A history of genetic disorders
3. A history of chromosomal abnormalities
4. A history of birth defects
5. Exposure to certain environmental factors, such as alcohol or drugs during pregnancy
6. Maternal age over 35
7. Low birth weight
8. Premature birth

At this time, there is no known cure for familial clubfoot due to 17q23.1q23.2 microduplication. However, there are treatments available to help manage the condition. These include physical therapy, casting, and surgery. Medications such as muscle relaxants and pain relievers may also be prescribed to help manage symptoms.