Familial Alzheimer-like prion disease (FAD) is a rare, inherited form of dementia caused by a mutation in the gene that produces the prion protein. It is characterized by memory loss, confusion, and changes in behavior similar to those seen in Alzheimer's disease. FAD is caused by a mutation in the gene that produces the prion protein, which is responsible for normal brain function. The mutation causes the prion protein to become misfolded and accumulate in the brain, leading to the development of the disease.

The symptoms of Familial Alzheimer-like prion disease (FAD) are similar to those of Alzheimer’s disease, but usually appear earlier in life. Symptoms may include:

• Memory loss

• Difficulty concentrating

• Confusion

• Difficulty with language

• Changes in behavior

• Loss of coordination

• Visual disturbances

• Seizures

• Difficulty walking

• Loss of bladder and bowel control

• Personality changes

• Depression

• Anxiety

• Hallucinations

• Paranoia

Familial Alzheimer-like prion disease is caused by a mutation in the gene that codes for the prion protein (PRNP). This mutation causes the prion protein to become misfolded and accumulate in the brain, leading to the development of the disease.

Currently, there is no known cure for Familial Alzheimer-like prion disease. Treatment focuses on managing symptoms and providing supportive care. This may include medications to help manage behavioral symptoms, physical therapy to help maintain mobility, and occupational therapy to help with daily activities. Additionally, supportive care such as counseling and respite care may be beneficial.

1. Having a family history of Familial Alzheimer-like prion disease.
2. Being of a certain ethnic background, such as Ashkenazi Jewish.
3. Having a mutation in the PRNP gene.
4. Being over the age of 60.
5. Having a history of head trauma.
6. Having a history of exposure to certain environmental toxins.
7. Having a history of certain medical conditions, such as diabetes or stroke.

At this time, there is no cure or medications available for Familial Alzheimer-like prion disease. However, there are treatments available to help manage the symptoms of the disease, such as medications to help with memory and behavior, physical and occupational therapy, and supportive care.