Factor XI Deficiency is a rare inherited bleeding disorder caused by a deficiency of the clotting factor XI. People with this disorder have a reduced ability to form blood clots, which can lead to excessive bleeding. Symptoms may include easy bruising, prolonged bleeding from cuts, and heavy menstrual bleeding. Treatment typically involves the use of clotting factor concentrates to replace the missing factor XI.

The symptoms of Factor XI Deficiency can vary from person to person, but may include:

-Easy bruising
-Excessive bleeding from cuts or injuries
-Prolonged bleeding after surgery or dental procedures
-Heavy menstrual bleeding
-Nosebleeds
-Blood in the urine or stool
-Joint Pain or swelling due to bleeding into the joint
-Fatigue
-Headaches
-Dizziness

Factor XI Deficiency is an inherited disorder caused by mutations in the F11 gene. These mutations can be passed down from either parent, and can be either inherited in an autosomal recessive or autosomal dominant pattern. Other causes of Factor XI Deficiency include acquired conditions such as liver disease, kidney disease, and certain medications.

The main treatment for Factor XI Deficiency is prophylactic treatment with a blood-clotting factor concentrate. This is usually given as an injection every two to four weeks. Other treatments may include antifibrinolytic drugs, such as tranexamic acid, to reduce bleeding episodes, and vitamin K to help the body produce more clotting factors. In some cases, a splenectomy (surgical removal of the spleen) may be recommended to reduce the risk of bleeding.

1. Family history of Factor XI Deficiency
2. Ashkenazi Jewish ancestry
3. Certain genetic mutations
4. Certain medications, such as heparin
5. Liver disease
6. Pregnancy
7. Age (older adults are more likely to develop the condition)
8. Certain medical conditions, such as kidney failure or lupus

Yes, there are treatments available for Factor XI Deficiency. Treatment typically involves the use of a medication called NovoSeven (recombinant factor VIIa) to replace the missing factor XI. This medication is administered intravenously and can help to reduce the risk of bleeding episodes. Other medications, such as antifibrinolytics, may also be used to help reduce the risk of bleeding.