About Factor VII Deficiency

What is Factor VII Deficiency?

Factor VII Deficiency is a rare inherited disorder in which the body does not produce enough of a protein called factor VII. This protein is necessary for the normal clotting of blood. People with this disorder may experience excessive bleeding after minor injuries or surgery, and may be at risk for life-threatening bleeding episodes. Treatment typically involves replacement therapy with factor VII concentrates.

What are the symptoms of Factor VII Deficiency?

Symptoms of Factor VII Deficiency can vary from person to person, but may include:

-Easy bruising
-Excessive bleeding from cuts or injuries
-Prolonged bleeding from dental procedures
-Heavy menstrual bleeding
-Nosebleeds
-Blood in the urine or stool
-Joint pain
-Fatigue
-Headaches
-Weakness

What are the causes of Factor VII Deficiency?

Factor VII Deficiency is caused by a genetic mutation that affects the body's ability to produce Factor VII, a protein involved in the clotting process. Other causes of Factor VII Deficiency include liver disease, vitamin K deficiency, and certain medications.

What are the treatments for Factor VII Deficiency?

The main treatment for Factor VII Deficiency is replacement therapy, which involves receiving regular infusions of a clotting factor concentrate. This concentrate is made from donated human plasma and contains the missing clotting factor. Other treatments may include medications to reduce the risk of blood clots, such as anticoagulants, and lifestyle changes to reduce the risk of bleeding. In some cases, surgery may be necessary to stop bleeding.

What are the risk factors for Factor VII Deficiency?

1. Family history of Factor VII Deficiency
2. Genetic mutations
3. Liver disease
4. Certain medications
5. Vitamin K deficiency
6. Malnutrition
7. Severe trauma or surgery
8. Pregnancy

Is there a cure/medications for Factor VII Deficiency?

Yes, there is a treatment for Factor VII Deficiency. Treatment typically involves the use of a medication called recombinant factor VIIa (rFVIIa). This medication helps to replace the missing factor VII in the blood and can help to reduce the risk of bleeding episodes. Other treatments may include blood transfusions, vitamin K supplements, and other medications to help reduce the risk of bleeding.