About Exfoliative ichthyosis

What is Exfoliative ichthyosis?

Exfoliative ichthyosis is a rare, inherited skin disorder characterized by thick, dry, scaly skin. It is caused by a mutation in the gene that controls the production of a protein called transglutaminase 1. This protein helps to form the protective outer layer of the skin. People with exfoliative ichthyosis have a defective form of this protein, which causes the skin to become thick and scaly. The condition can cause itching, pain, and discomfort. Treatment typically involves the use of topical medications and moisturizers to help reduce the symptoms.

What are the symptoms of Exfoliative ichthyosis?

The main symptom of exfoliative ichthyosis is dry, thickened, and scaly skin. The skin may be reddish-brown in color and may crack and bleed. Other symptoms may include:

• Itching

• Crusting of the skin

• Thickening of the skin on the palms and soles

• Thickening of the skin on the scalp

• Thickening of the skin around the eyes, nose, and mouth

• Thickening of the skin on the neck and chest

• Thickening of the skin on the elbows and knees

• Thickening of the skin on the back and buttocks

• Thickening of the skin on the genitals

• Thickening of the skin on the fingers and toes

• Thickening of the skin on the arms and legs

What are the causes of Exfoliative ichthyosis?

Exfoliative ichthyosis is a rare genetic skin disorder caused by mutations in the transglutaminase 1 (TGM1) gene. This gene is responsible for producing an enzyme that helps to form the outer layer of the skin. Mutations in this gene can cause the skin to become dry, scaly, and thickened. In some cases, the skin may also become red and inflamed.

What are the treatments for Exfoliative ichthyosis?

The treatments for Exfoliative ichthyosis include topical retinoids, topical corticosteroids, topical calcineurin inhibitors, systemic retinoids, systemic immunosuppressants, and phototherapy.

What are the risk factors for Exfoliative ichthyosis?

1. Genetic predisposition: Exfoliative ichthyosis is an inherited disorder caused by a mutation in the gene that codes for the protein transglutaminase 1 (TGM1).

2. Age: Exfoliative ichthyosis is most commonly seen in infants and young children.

3. Gender: Exfoliative ichthyosis is more common in males than females.

4. Ethnicity: Exfoliative ichthyosis is more common in people of Asian and African descent.

Is there a cure/medications for Exfoliative ichthyosis?

There is no cure for exfoliative ichthyosis, but there are medications that can help manage the symptoms. These include topical retinoids, topical corticosteroids, and oral retinoids. Additionally, moisturizers and emollients can help keep the skin hydrated and reduce itching.