Erythema palmare hereditarium is a rare inherited skin condition characterized by redness and swelling of the palms of the hands. It is caused by a mutation in the gene that codes for the enzyme lysyl oxidase, which is involved in the formation of collagen and elastin. Symptoms usually begin in childhood and may include redness, swelling, and itching of the palms. In some cases, the condition may also cause thickening of the skin on the palms. Treatment typically involves topical corticosteroids and antihistamines.

The primary symptom of Erythema palmare hereditarium is the presence of red, scaly patches on the palms of the hands. These patches may be itchy and may cause Burning or stinging sensations. Other symptoms may include dryness, cracking, and peeling of the skin on the palms. In some cases, the patches may spread to the soles of the feet.

Erythema palmare hereditarium is a rare skin condition that is caused by a genetic mutation. The exact cause of the mutation is unknown, but it is believed to be inherited in an autosomal dominant pattern. It is thought to be caused by a mutation in the gene that codes for the enzyme transglutaminase-1. This enzyme is involved in the formation of the skin's protective barrier.

1. Topical corticosteroids: These can be applied directly to the affected area to reduce inflammation and itching.

2. Phototherapy: This involves exposing the affected area to ultraviolet light to reduce inflammation and itching.

3. Oral medications: These can include antihistamines, antibiotics, and other medications to reduce inflammation and itching.

4. Laser therapy: This involves using a laser to reduce inflammation and itching.

5. Surgery: In some cases, surgery may be necessary to remove the affected skin.

1. Family history of the condition
2. Being of European descent
3. Being female
4. Exposure to ultraviolet light
5. Certain medications, such as anticonvulsants, antibiotics, and nonsteroidal anti-inflammatory drugs
6. Stress
7. Hormonal changes, such as during pregnancy or menopause
8. Skin trauma or irritation

There is no known cure for erythema palmare hereditarium. Treatment is usually focused on managing the symptoms, which may include topical corticosteroids, oral antihistamines, and phototherapy.