EN1-related dorsoventral syndrome is a rare genetic disorder caused by mutations in the EN1 gene. It is characterized by a variety of physical and neurological abnormalities, including skeletal malformations, intellectual disability, and seizures. Affected individuals may also have facial dysmorphism, hearing loss, and vision problems.

The symptoms of EN1-related dorsoventral syndrome vary from person to person, but may include:

-Developmental delay
-Intellectual disability
-Seizures
-Movement disorders
-Growth delays
-Feeding difficulties
-Hearing loss
-Vision problems
-Heart defects
-Abnormalities of the spine
-Abnormalities of the hands and feet
-Abnormalities of the face and skull
-Abnormalities of the kidneys and urinary tract

EN1-related dorsoventral syndrome is caused by mutations in the EN1 gene. This gene is responsible for producing a protein called engrailed-1, which is involved in the development of the nervous system. Mutations in the EN1 gene can lead to a variety of neurological and physical abnormalities, including dorsoventral syndrome.

The treatments for EN1-related dorsoventral syndrome vary depending on the severity of the condition. Generally, treatment focuses on managing the symptoms and improving quality of life. This may include physical therapy, occupational therapy, speech therapy, and orthopedic surgery. Medications may also be prescribed to help manage pain and muscle spasms. In some cases, genetic counseling may be recommended to help families understand the condition and its implications.

1. Maternal advanced age
2. Family history of EN1-related dorsoventral syndrome
3. Genetic mutations in the EN1 gene
4. Exposure to certain environmental toxins
5. Low birth weight
6. Premature birth
7. Exposure to certain medications during pregnancy

At this time, there is no known cure or medications for EN1-related dorsoventral syndrome. Treatment is focused on managing the symptoms and providing supportive care. This may include physical therapy, occupational therapy, speech therapy, and other interventions to help improve the patient's quality of life.