Ectodermal dysplasia-syndactyly syndrome (EDSS) is a rare genetic disorder that affects the development of the skin, hair, nails, teeth, and sweat glands. It is characterized by the abnormal development of these structures, as well as the fusion of certain fingers and toes (syndactyly). Symptoms may include dry, scaly skin; sparse, brittle hair; and missing or malformed teeth. Other features may include hearing loss, vision problems, and intellectual disability. Treatment is based on the individual's symptoms and may include skin care, dental care, and hearing aids.

The symptoms of Ectodermal Dysplasia-Syndactyly Syndrome (EDSS) vary depending on the type of EDSS, but may include:

- Abnormalities of the skin, hair, and nails, including dry, scaly skin, sparse or absent scalp and body hair, and brittle, slow-growing nails
- Abnormalities of the teeth, including missing, malformed, or discolored teeth
- Abnormalities of the sweat glands, including decreased or absent sweating
- Abnormalities of the eyes, including small eyes, droopy eyelids, and vision problems
- Abnormalities of the hands and feet, including webbed fingers and toes, extra fingers and toes, and missing or malformed fingers and toes
- Abnormalities of the ears, including small, malformed,

Ectodermal dysplasia-syndactyly syndrome is caused by mutations in the TP63 gene. This gene is responsible for the production of a protein that helps regulate the development of the skin, hair, nails, teeth, and sweat glands. Mutations in this gene can lead to the development of the syndrome.

1. Orthodontic treatment: This may include braces, retainers, and other orthodontic appliances to help correct the malocclusion (misalignment of the teeth) caused by the syndrome.

2. Surgery: Surgery may be necessary to correct the syndactyly (webbed fingers and toes) and other physical deformities associated with the syndrome.

3. Skin care: Special skin care products and techniques may be necessary to help keep the skin healthy and prevent infection.

4. Wearing protective clothing: Wearing protective clothing, such as gloves and socks, can help protect the skin from further damage.

5. Physical therapy: Physical therapy may be necessary to help improve mobility and strength.

6. Speech therapy: Speech therapy may be necessary to help improve communication skills.

7. Psychological

1. Genetic inheritance: Ectodermal dysplasia-syndactyly syndrome is an inherited disorder, meaning it is passed down from parents to their children.

2. Mutations: Mutations in the TP63 gene are responsible for the syndrome.

3. Environmental factors: Exposure to certain environmental factors, such as certain medications or chemicals, may increase the risk of developing the syndrome.

4. Family history: Having a family history of the syndrome increases the risk of developing it.

There is no cure for ectodermal dysplasia-syndactyly syndrome, but there are treatments available to manage the symptoms. These treatments may include medications to help with skin and hair problems, physical therapy to help with joint and muscle problems, and surgery to correct any physical deformities.