Early-onset autoimmunity-autoinflammation-immunodeficiency syndrome (EAI-AID) is a rare, inherited disorder that affects the immune system. It is characterized by recurrent episodes of inflammation, autoimmunity, and immunodeficiency. Symptoms may include recurrent infections, skin rashes, joint pain, and fever. EAI-AID is caused by mutations in certain genes that are involved in the regulation of the immune system. Treatment typically involves medications to reduce inflammation and suppress the immune system.