Dubin-Johnson Syndrome is a rare inherited disorder that affects the liver. It is caused by a mutation in the gene responsible for the production of the enzyme glucuronosyltransferase. Symptoms of the disorder include jaundice, dark urine, and abdominal pain. It is usually diagnosed through a liver biopsy. Treatment typically involves medications to reduce the symptoms and lifestyle changes to reduce the risk of complications.

The most common symptoms of Dubin-Johnson Syndrome include dark urine, jaundice, abdominal pain, and fatigue. Other symptoms may include nausea, vomiting, loss of appetite, and itching. In some cases, people with Dubin-Johnson Syndrome may also experience joint pain, fever, and weight loss.

Dubin-Johnson Syndrome is an inherited disorder caused by mutations in the ABCC2 gene. This gene provides instructions for making a protein that helps transport certain substances out of cells. Mutations in this gene lead to an accumulation of certain substances, such as bilirubin, in the liver and other tissues.

The primary treatment for Dubin-Johnson Syndrome is to manage the symptoms. This may include medications to reduce the amount of bilirubin in the blood, such as cholestyramine or rifampin. Other treatments may include dietary changes, such as avoiding foods high in fat, and avoiding alcohol. In some cases, a liver transplant may be necessary.

The exact cause of Dubin-Johnson Syndrome is unknown, but it is believed to be an inherited disorder. Risk factors for Dubin-Johnson Syndrome include having a family history of the disorder, being of Asian or African descent, and having certain genetic mutations.

There is no cure for Dubin-Johnson Syndrome, but medications can be used to help manage the symptoms. These medications include cholestyramine, ursodeoxycholic acid, and rifampin. Additionally, lifestyle changes such as avoiding alcohol and certain medications, eating a healthy diet, and exercising regularly can help manage symptoms.