About Drug-induced vasculitis

What is Drug-induced vasculitis?

Drug-induced vasculitis is a type of vasculitis (inflammation of the blood vessels) that is caused by a reaction to certain medications. It can cause a wide range of symptoms, including skin rashes, joint pain, fever, and fatigue. In some cases, it can also lead to organ damage. Treatment typically involves stopping the medication that is causing the reaction and taking medications to reduce inflammation.

What are the symptoms of Drug-induced vasculitis?

The symptoms of drug-induced vasculitis can vary depending on the type of drug and the severity of the reaction. Common symptoms include:

-Skin rash


-Joint Pain and swelling

-Muscle aches


-Weight loss

-Nausea and vomiting

-Abdominal pain


-Shortness of breath

-Chest pain

-Sensitivity to light


-Blood in the urine or stool

What are the causes of Drug-induced vasculitis?

Drug-induced vasculitis is caused by an allergic reaction to certain medications. Common medications that can cause drug-induced vasculitis include antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and chemotherapy drugs. Other causes of drug-induced vasculitis include infections, autoimmune diseases, and exposure to certain toxins.

What are the treatments for Drug-induced vasculitis?

1. Discontinuing the offending drug: The first step in treating drug-induced vasculitis is to discontinue the offending drug.

2. Corticosteroids: Corticosteroids are the mainstay of treatment for drug-induced vasculitis. They help reduce inflammation and suppress the immune system.

3. Immunosuppressants: Immunosuppressants such as cyclophosphamide, azathioprine, and methotrexate may be used to further suppress the immune system and reduce inflammation.

4. Antihistamines: Antihistamines such as diphenhydramine may be used to reduce symptoms such as itching and hives.

5. Antibiotics: Antibiotics may be used to treat any secondary infections that may occur due to the weakened immune system.

What are the risk factors for Drug-induced vasculitis?

1. Certain medications, including antibiotics, anticonvulsants, nonsteroidal anti-inflammatory drugs (NSAIDs), and antineoplastic drugs.

2. Exposure to certain chemicals, such as insecticides, solvents, and hair dyes.

3. Infections, including hepatitis B and C, HIV, and certain parasites.

4. Autoimmune diseases, such as lupus and rheumatoid arthritis.

5. Genetic predisposition.

6. Age, with drug-induced vasculitis more common in people over the age of 60.

7. Gender, with women more likely to develop drug-induced vasculitis than men.

Is there a cure/medications for Drug-induced vasculitis?

Yes, there are treatments available for drug-induced vasculitis. Treatment typically involves discontinuing the drug that is causing the vasculitis, and then treating the inflammation with corticosteroids or other immunosuppressive medications. In some cases, additional medications such as antimalarials or biologics may be used.