Currently, there is no cure for DNAJB6-related limb-girdle muscular dystrophy D1. Treatment focuses on managing symptoms and preventing complications. Treatment may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to help manage muscle weakness and pain. In some cases, surgery may be recommended to correct joint deformities or to help improve mobility. Genetic counseling may also be recommended to help individuals and families understand the condition and its implications.