Diffuse large B-cell lymphoma of the central nervous system (DLBCL-CNS) is a rare type of non-Hodgkin lymphoma that affects the brain and spinal cord. It is a type of B-cell lymphoma, which is a cancer of the white blood cells. DLBCL-CNS is an aggressive form of cancer that can spread quickly and is difficult to treat. Symptoms of DLBCL-CNS can include headaches, seizures, confusion, and changes in behavior. Treatment typically involves a combination of chemotherapy, radiation therapy, and/or surgery.