Diaphragmatic hernia-short bowel-asplenia syndrome is a rare congenital disorder characterized by a combination of diaphragmatic hernia, short bowel syndrome, and asplenia. Diaphragmatic hernia is a birth defect in which the diaphragm, the muscle that separates the chest from the abdomen, does not form properly, allowing abdominal organs to move into the chest cavity. Short bowel syndrome is a condition in which the small intestine is unable to absorb enough nutrients from food, leading to malnutrition and dehydration. Asplenia is a condition in which the spleen does not function properly, leading to an increased risk of infection. People with this syndrome may require lifelong medical care and nutritional support.