Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome (DGMS) is a rare genetic disorder characterized by hearing loss, genital anomalies, and fusion of the bones in the hands and feet (metacarpal and metatarsal synostosis). Affected individuals may also have other skeletal abnormalities, including short stature, scoliosis, and joint contractures. The hearing loss is usually sensorineural and may be mild to profound. The genital anomalies may include undescended testes, hypospadias, and micropenis in males, and labial fusion and clitoral enlargement in females. Treatment is based on the individual's symptoms and may include hearing aids, surgery, and physical therapy.

The symptoms of Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome (DGMS) include:

• Hearing loss
• Abnormal genitalia
• Abnormalities of the hands and feet, including fusion of the metacarpal and metatarsal bones
• Abnormalities of the face, including a broad nasal bridge, a flat midface, and a small lower jaw
• Intellectual disability
• Seizures
• Abnormalities of the eyes, including strabismus and cataracts
• Abnormalities of the heart, including ventricular septal defect and patent ductus arteriosus
• Abnormalities of the kidneys, including renal dysplasia and cystic kidneys
• Abnormalities of the gastrointestinal tract, including esophageal at

1. Genetic mutations: Certain genetic mutations can cause deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome.

2. Environmental factors: Exposure to certain environmental factors such as certain medications, infections, and toxins can also cause this syndrome.

3. Chromosomal abnormalities: Abnormalities in the chromosomes can also lead to this syndrome.

4. Unknown causes: In some cases, the cause of this syndrome is unknown.

Treatment for Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome is typically focused on managing the individual symptoms. This may include hearing aids or cochlear implants to help with hearing loss, surgery to correct any genital anomalies, and physical therapy to help with any mobility issues caused by the metacarpal and metatarsal synostosis. Additionally, genetic counseling may be recommended to help families understand the condition and its potential implications.

1. Genetic mutation: Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome is caused by a mutation in the GJB2 gene.

2. Family history: Having a family history of the condition increases the risk of developing the syndrome.

3. Ethnicity: The syndrome is more common in certain ethnic groups, such as Ashkenazi Jews.

4. Age: The syndrome is more common in infants and young children.

Unfortunately, there is no known cure or medications for Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome. Treatment for this condition is focused on managing the symptoms and providing supportive care. This may include hearing aids, speech therapy, physical therapy, and surgery to correct any physical deformities.