Cronkhite-Canada Syndrome (CCS) is a rare, non-inherited disorder of the gastrointestinal tract. It is characterized by the sudden onset of multiple gastrointestinal symptoms, including diarrhea, weight loss, anorexia, and nail changes. It is also associated with the development of polyps in the stomach and intestines. The cause of CCS is unknown, but it is thought to be related to an autoimmune process. Treatment typically involves dietary modifications, medications, and surgery.