Cree leukoencephalopathy is a rare, progressive neurological disorder that affects the brain and spinal cord. It is found primarily in the Cree population of Canada, and is characterized by progressive neurological decline, including cognitive and motor impairment, seizures, and spasticity. It is caused by a mutation in the gene that encodes the enzyme cystathionine beta-synthase.

The symptoms of Cree leukoencephalopathy vary from person to person, but may include:

-Developmental delay
-Seizures
-Loss of motor skills
-Loss of speech
-Difficulty walking
-Difficulty swallowing
-Vision and hearing loss
-Behavioral problems
-Cognitive impairment
-Muscle weakness
-Abnormal movements

Cree leukoencephalopathy is a rare neurological disorder that is caused by a mutation in the gene that encodes the enzyme cystathionine beta-synthase (CBS). This mutation results in a deficiency of the enzyme, which is responsible for the metabolism of the amino acid homocysteine. The accumulation of homocysteine in the brain leads to the development of the disorder. Other causes of Cree leukoencephalopathy include exposure to environmental toxins, such as lead, and genetic factors.

The treatments for Cree leukoencephalopathy are mainly supportive and symptomatic. These include physical therapy, occupational therapy, speech therapy, and medications to help manage seizures and other symptoms. Other treatments may include dietary modifications, vitamin supplementation, and stem cell therapy.

The primary risk factor for Cree leukoencephalopathy is being of Cree ancestry. Other risk factors include living in a rural area, having a family history of the disorder, and being exposed to environmental toxins.

At this time, there is no known cure for Cree leukoencephalopathy. However, there are medications that can help manage the symptoms of the disorder. These medications include anticonvulsants, anti-inflammatory drugs, and medications to help with sleep disturbances. Additionally, physical and occupational therapy can help improve motor skills and coordination.