Craniofrontonasal dysplasia is a rare genetic disorder that affects the development of the skull, face, and limbs. It is caused by a mutation in the ephrin-B1 gene. Symptoms of this disorder can include a wide forehead, a broad nasal bridge, a wide-set eyes, a cleft lip or palate, and malformations of the hands and feet. Other features may include hearing loss, vision problems, and intellectual disability. Treatment for this disorder is based on the individual's symptoms and may include surgery, physical therapy, and speech therapy.

The symptoms of Craniofrontonasal Dysplasia vary from person to person, but may include:

-Widely spaced eyes
-Widely spaced nipples
-Widely spaced fingers and toes
-Low-set ears
-Underdeveloped nasal bridge
-Widely spaced teeth
-Short stature
-Cleft palate
-Abnormalities of the skull
-Abnormalities of the hands and feet
-Abnormalities of the genitalia
-Abnormalities of the eyes
-Hearing loss
-Intellectual disability
-Delayed development

Craniofrontonasal Dysplasia is a rare genetic disorder caused by mutations in the ephrin-B1 gene. The exact cause of the mutation is unknown, but it is believed to be inherited in an autosomal dominant pattern, meaning that only one copy of the mutated gene is necessary for a person to be affected by the disorder.

Currently, there is no cure for Craniofrontonasal Dysplasia. Treatment is focused on managing the symptoms and complications associated with the condition. Treatment may include physical therapy, occupational therapy, speech therapy, and orthopedic surgery to correct skeletal abnormalities. In some cases, corrective surgery may be recommended to improve facial appearance. Genetic counseling may also be recommended for individuals and families affected by the condition.

1. Genetic mutation in the ephrin-B1 gene
2. Family history of the disorder
3. Maternal exposure to certain medications or environmental toxins during pregnancy
4. Maternal age over 35
5. Maternal diabetes or obesity

At this time, there is no cure for Craniofrontonasal Dysplasia. However, there are medications and treatments available to help manage the symptoms. These include physical therapy, speech therapy, occupational therapy, and medications to help with pain, seizures, and other symptoms. Surgery may also be recommended to correct any physical deformities.