Craniofrontonasal dysplasia-Poland anomaly syndrome is a rare genetic disorder characterized by a combination of physical abnormalities that affect the head, face, and chest. It is caused by a mutation in the ephrin-B1 gene. Symptoms may include a wide-set eyes, a broad nasal bridge, a cleft lip and/or palate, a small lower jaw, and a sunken chest. Other features may include webbed fingers and toes, hearing loss, and heart defects. Treatment is based on the individual's symptoms and may include surgery, physical therapy, and speech therapy.