Crandall syndrome is a rare genetic disorder characterized by the development of multiple cysts in the kidneys. It is caused by a mutation in the FAM20A gene, which is responsible for the production of a protein involved in the formation of teeth and bones. Symptoms of Crandall syndrome include kidney cysts, high blood pressure, proteinuria, and kidney failure. Treatment typically involves medications to control blood pressure and reduce the risk of kidney failure.

The most common symptoms of Crandall syndrome include:

-Delayed growth and development
-Intellectual disability
-Seizures
-Feeding difficulties
-Gastrointestinal problems
-Facial abnormalities
-Hearing loss
-Eye abnormalities
-Joint contractures
-Scoliosis
-Cardiac defects
-Respiratory problems
-Kidney abnormalities
-Skin abnormalities

Crandall syndrome is a rare genetic disorder caused by mutations in the NEMO gene. The NEMO gene provides instructions for making a protein that is involved in the activation of other proteins that are important for normal immune system function. Mutations in the NEMO gene lead to a decrease in the amount of functional NEMO protein, which disrupts the normal functioning of the immune system and causes the signs and symptoms of Crandall syndrome.

Currently, there is no known cure for Crandall syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, speech therapy, and orthopedic surgery. Medications may also be prescribed to help manage pain, seizures, and other symptoms. In some cases, a feeding tube may be necessary to ensure adequate nutrition.

The exact cause of Crandall syndrome is unknown, but it is believed to be an inherited disorder. Risk factors for Crandall syndrome include having a family history of the disorder, being of Ashkenazi Jewish descent, and having a mutation in the NSDHL gene.

At this time, there is no cure for Crandall syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. Medications may be prescribed to help manage pain, muscle spasms, and seizures. Physical and occupational therapy may also be recommended to help improve mobility and strength.