Corpus callosum agenesis-abnormal genitalia syndrome is a rare genetic disorder characterized by the absence of the corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain, and abnormal genitalia. It is caused by a mutation in the gene that codes for the protein called L1CAM. Symptoms of this disorder can include intellectual disability, seizures, vision and hearing problems, and motor delays. In addition, affected individuals may have genital abnormalities such as undescended testes, hypospadias, and micropenis. Treatment is based on the individual's symptoms and may include physical therapy, speech therapy, and medications.