The treatments for Cornelia de Lange Syndrome vary depending on the individual and the severity of the condition. Generally, treatment focuses on managing the physical, cognitive, and behavioral symptoms of the condition. This may include physical therapy, occupational therapy, speech therapy, and behavioral therapy. Medications may also be prescribed to help manage any associated medical conditions, such as seizures, gastrointestinal issues, and sleep disturbances. Additionally, surgery may be recommended to correct any physical deformities or to improve the function of certain organs.