Connective tissue disorder due to lysyl hydroxylase-3 deficiency is a rare genetic disorder that affects the production of collagen and elastin, two proteins that are important for the structure and function of connective tissues. This disorder is caused by mutations in the PLOD3 gene, which provides instructions for making an enzyme called lysyl hydroxylase-3. This enzyme is involved in the production of collagen and elastin. People with this disorder have reduced levels of lysyl hydroxylase-3, which leads to a decrease in the production of collagen and elastin. Symptoms of this disorder can include joint laxity, joint pain, and skeletal deformities.