Congenital plasminogen deficiency is a rare inherited disorder that affects the body's ability to break down proteins. It is caused by a mutation in the PLG gene, which provides instructions for making the plasminogen protein. This protein is involved in the breakdown of proteins in the body, and when it is deficient, proteins can accumulate in the blood and tissues, leading to a variety of symptoms. Symptoms may include recurrent infections, delayed wound healing, and abnormal bleeding. Treatment typically involves replacing the missing plasminogen protein with a medication.