Yes, there are treatments available for Congenital myasthenic syndromes with glycosylation defect. Treatment options include medications, physical therapy, and surgery. Medications used to treat this condition include acetylcholinesterase inhibitors, immunosuppressants, and other drugs that help to improve muscle strength and reduce fatigue. Physical therapy can help to improve muscle strength and coordination. Surgery may be recommended in some cases to correct structural abnormalities in the muscles or nerves.