Congenital muscular dystrophy with intellectual disability and severe epilepsy (CMDIDSE) is a rare genetic disorder characterized by progressive muscle weakness, intellectual disability, and severe epilepsy. It is caused by mutations in the POMT1 gene, which is responsible for the production of a protein called POMT1. This protein is essential for the proper functioning of the muscles and the brain. Symptoms of CMDIDSE include muscle weakness, muscle wasting, joint contractures, intellectual disability, and severe epilepsy. Treatment typically involves physical therapy, medications to control seizures, and supportive care.