Congenital lipoid adrenal hyperplasia due to STAR deficiency is a rare genetic disorder that affects the adrenal glands. It is caused by a mutation in the steroidogenic acute regulatory (STAR) protein, which is responsible for transporting cholesterol into the mitochondria of cells in the adrenal glands. This mutation results in a deficiency of the STAR protein, which leads to a decrease in the production of steroid hormones, such as cortisol and aldosterone. Symptoms of this disorder include low levels of cortisol, which can lead to fatigue, weight loss, and low blood pressure; and low levels of aldosterone, which can lead to dehydration, electrolyte imbalances, and low blood pressure. Treatment typically involves hormone replacement therapy and lifestyle modifications.