Congenital ichthyosis-intellectual disability-spastic quadriplegia syndrome is a rare genetic disorder characterized by the presence of congenital ichthyosis (a skin disorder), intellectual disability, and spastic quadriplegia (a type of paralysis). It is caused by a mutation in the PNPLA6 gene, which is responsible for the production of an enzyme involved in the breakdown of fats. Symptoms of this disorder include dry, scaly skin, seizures, developmental delays, and muscle stiffness and weakness. Treatment typically involves the use of topical medications to reduce skin dryness and moisturizers to keep the skin hydrated. Physical and occupational therapy may also be recommended to help improve muscle strength and coordination.