About Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies
What is Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies is a rare form of congenital hypothyroidism caused by the presence of maternal antibodies that bind to and inhibit the action of thyroid stimulating hormone (TSH). These antibodies are passed from the mother to the fetus through the placenta, resulting in decreased production of thyroid hormones in the fetus. This can lead to a variety of symptoms, including growth retardation, mental retardation, and delayed development. Treatment typically involves hormone replacement therapy.
What are the symptoms of Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
The symptoms of Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies can include:
- Poor feeding
- Constipation
- Lethargy
- Poor weight gain
- Jaundice
- Hoarse cry
- Poor muscle tone
- Umbilical hernia
- Large fontanelle
- Delayed development
- Goiter
- Hypothermia
- Hypotonia
What are the causes of Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
The exact cause of congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies is unknown. However, it is believed to be an autoimmune disorder, where the mother's immune system produces antibodies that attack the thyroid gland of the fetus. This can lead to a decrease in the production of thyroid hormones, resulting in hypothyroidism. Other possible causes include genetic mutations, iodine deficiency, and certain medications taken by the mother during pregnancy.
What are the treatments for Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
The primary treatment for congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies is hormone replacement therapy. This involves taking a daily dose of levothyroxine, a synthetic form of the thyroid hormone thyroxine (T4). This hormone replacement therapy helps to restore normal thyroid hormone levels and can help to improve growth and development. Other treatments may include dietary changes, such as increasing the intake of iodine-rich foods, and supplementing with selenium and zinc. In some cases, additional medications may be prescribed to help manage symptoms.
What are the risk factors for Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
1. Family history of autoimmune thyroid disease
2. Maternal history of thyroid dysfunction
3. Maternal history of autoimmune disease
4. Maternal history of exposure to environmental toxins
5. Maternal history of radiation exposure
6. Maternal history of viral infections
7. Maternal history of drug use
8. Maternal age over 35
9. Maternal iodine deficiency
10. Maternal obesity
Is there a cure/medications for Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?
There is no cure for congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies. However, the condition can be managed with lifelong hormone replacement therapy. This involves taking a daily dose of levothyroxine, a synthetic form of the thyroid hormone thyroxine. This medication helps to replace the hormones that the body is not producing, and helps to regulate the body's metabolism.