Congenital high-molecular-weight kininogen deficiency (CHMKD) is a rare inherited disorder caused by a mutation in the gene that codes for high-molecular-weight kininogen (HK). This gene is responsible for producing a protein that helps regulate the body’s clotting system. People with CHMKD have a deficiency of this protein, which can lead to excessive bleeding and bruising. In some cases, the disorder can also cause recurrent infections, anemia, and other complications. Treatment for CHMKD typically involves replacement therapy with a synthetic form of the missing protein.