Congenital Generalized Lipodystrophy (CGL) is a rare genetic disorder that affects the body's ability to store fat. It is characterized by a near complete absence of fat in the body, resulting in a thin, gaunt appearance. Other symptoms include enlarged liver and spleen, diabetes, and high levels of triglycerides in the blood. CGL is caused by mutations in one of several genes, and is usually diagnosed in childhood. Treatment typically involves managing the symptoms, such as controlling blood sugar levels and providing nutritional support.