Congenital bilateral megacalycosis is a rare condition in which a person is born with abnormally large kidneys. It is caused by an abnormal development of the kidneys in the womb, and can lead to a variety of health problems, including high blood pressure, kidney failure, and urinary tract infections. Treatment typically involves medications to control blood pressure and other symptoms, as well as surgery to remove the enlarged kidneys.

The symptoms of Congenital bilateral megacalycosis include:

-Enlarged kidneys
-High blood pressure
-Proteinuria (excess protein in the urine)
-Edema (swelling)
-Abdominal pain
-Frequent urination
-Fatigue
-Nausea
-Vomiting
-Weight loss
-Decreased appetite
-Itching
-Dark urine
-Blood in the urine
-Fever
-Pain in the side or back

Congenital bilateral megacalycosis is a rare condition that is caused by a genetic mutation. It is caused by a mutation in the gene that codes for the enzyme carbonic anhydrase II (CAII). This enzyme is responsible for the production of bicarbonate ions, which are important for maintaining the acid-base balance in the body. When this enzyme is mutated, it can lead to an accumulation of bicarbonate ions in the kidneys, resulting in the formation of large cysts in the kidneys. Other causes of congenital bilateral megacalycosis include genetic syndromes such as autosomal dominant polycystic kidney disease, tuberous sclerosis, and von Hippel-Lindau disease.

1. Surgery: Surgery is the most common treatment for congenital bilateral megacalycosis. The goal of surgery is to remove the enlarged adrenal glands and restore normal adrenal function.

2. Medication: Medications such as corticosteroids and mineralocorticoids can be used to help control symptoms and reduce the size of the adrenal glands.

3. Diet and lifestyle changes: Making changes to your diet and lifestyle can help reduce the symptoms of congenital bilateral megacalycosis. Eating a healthy diet, avoiding stress, and getting regular exercise can all help.

4. Alternative therapies: Alternative therapies such as acupuncture, yoga, and meditation can help reduce stress and improve overall health.

1. Maternal diabetes
2. Maternal obesity
3. Maternal smoking
4. Maternal alcohol consumption
5. Maternal age over 35
6. Maternal use of certain medications
7. Family history of congenital megacalycosis
8. Exposure to certain environmental toxins
9. Genetic mutations or chromosomal abnormalities

At this time, there is no known cure for congenital bilateral megacalycosis. Treatment typically involves medications to reduce the size of the enlarged kidneys and to manage any associated symptoms. These medications may include diuretics, ACE inhibitors, and angiotensin receptor blockers. In some cases, surgery may be recommended to remove the enlarged kidneys.