1. Genetic predisposition: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency is an autosomal recessive disorder, meaning that it is inherited from both parents.
2. Ethnicity: This disorder is more common in certain ethnic groups, such as Ashkenazi Jews, Hispanics, and African Americans.
3. Family history: If a family member has the disorder, there is an increased risk of developing it.
4. Exposure to certain medications: Certain medications, such as spironolactone, can increase the risk of developing this disorder.