Treatment for Combined oxidative phosphorylation defect type 2 (COXPD2) is largely supportive and symptomatic. Treatment may include dietary modifications, such as a low-fat diet, and supplementation with carnitine, coenzyme Q10, and riboflavin. Antioxidants, such as vitamin E, may also be recommended. In some cases, medications such as anticonvulsants may be prescribed to help manage seizures. Physical therapy and occupational therapy may also be recommended to help improve muscle strength and coordination. In severe cases, a heart transplant may be necessary.