Combined deficiency of factor VII and factor X is a rare inherited disorder known as combined factor VII and X deficiency. It is caused by mutations in the F7 and F10 genes, which are responsible for producing the proteins factor VII and factor X, respectively. People with this disorder have a reduced level of both proteins, which can lead to excessive bleeding. Treatment typically involves the use of replacement clotting factors to help control bleeding episodes.

The symptoms of combined deficiency of factor VII and factor X include prolonged bleeding after minor cuts or injuries, easy bruising, nosebleeds, and heavy menstrual bleeding. Other symptoms may include blood in the urine or stool, joint pain, and fatigue.

Combined deficiency of factor VII and factor X is caused by mutations in the F7 and F10 genes, which are responsible for producing the proteins that make up these two clotting factors. Mutations in either gene can cause a deficiency in both factors. Other causes of combined deficiency of factor VII and factor X include inherited disorders such as hemophilia A, lupus anticoagulant, and antithrombin III deficiency.

The treatment for combined deficiency of factor VII and factor X is replacement therapy with a combination of factor VII and factor X concentrates. This therapy is usually given intravenously and can be used to prevent or treat bleeding episodes. In some cases, prophylactic therapy may be recommended to prevent bleeding episodes. Other treatments may include vitamin K supplementation, antifibrinolytic agents, and desmopressin.

1. Inherited genetic mutations
2. Liver disease
3. Vitamin K deficiency
4. Certain medications
5. Malnutrition
6. Alcoholism
7. Severe trauma
8. Certain infections

There is no cure for combined deficiency of factor VII and factor X. Treatment typically involves replacement therapy with clotting factors, such as fresh frozen plasma or recombinant factor VIIa. Medications such as anticoagulants may also be prescribed to help prevent blood clots.