The main treatment for Cogan syndrome is corticosteroids, such as prednisone, to reduce inflammation and suppress the immune system. Other treatments may include immunosuppressants, such as cyclophosphamide, azathioprine, or methotrexate, to reduce inflammation and suppress the immune system. In some cases, antibiotics may be prescribed to treat any underlying infections. In severe cases, intravenous immunoglobulin (IVIG) may be used to reduce inflammation. Surgery may be necessary to repair any damage to the inner ear.