The treatments for Coffin Siris Syndrome vary depending on the individual and the severity of the condition. Generally, treatment focuses on managing the symptoms and providing supportive care. This may include physical therapy, occupational therapy, speech therapy, and other therapies to help with motor skills, communication, and socialization. Medications may also be prescribed to help with seizures, sleep disturbances, and other medical issues. Surgery may be recommended to correct physical abnormalities. Genetic counseling may also be recommended to help families understand the condition and plan for the future.