Cloverleaf skull-multiple congenital anomalies syndrome is a rare genetic disorder characterized by a distinctive skull shape, multiple congenital anomalies, and intellectual disability. It is caused by a mutation in the gene that codes for the protein filamin A. Symptoms of the disorder include a cloverleaf-shaped skull, facial abnormalities, developmental delays, and intellectual disability. Other features may include hearing loss, vision problems, and heart defects. Treatment is supportive and may include physical and occupational therapy, speech therapy, and medications to manage symptoms.