Classical-like Ehlers-Danlos syndrome type 1 (EDS type 1) is a rare inherited connective tissue disorder that affects the skin, joints, and blood vessels. It is caused by a defect in the gene that produces collagen, a protein that provides structure and strength to the body's tissues. People with EDS type 1 have fragile skin that bruises easily, joint hypermobility, and an increased risk of arterial and organ rupture.

The symptoms of Classical-like Ehlers-Danlos syndrome type 1 can vary from person to person, but may include:

-Joint hypermobility
-Joint dislocations and subluxations
-Skin hyperextensibility
-Fragile skin that bruises easily
-Atrophic scarring
-Easy fatigability
-Chronic musculoskeletal pain
-Gastrointestinal problems
-Cardiovascular problems
-Scoliosis
-Kyphoscoliosis
-Ocular problems
-Dental problems
-Craniofacial dysmorphism
-Cognitive and behavioral problems

Classical-like Ehlers-Danlos syndrome type 1 is caused by mutations in the COL5A1 gene, which is responsible for producing type V collagen. Mutations in this gene can lead to a decrease in the amount of type V collagen produced, resulting in the symptoms of Classical-like Ehlers-Danlos syndrome type 1.

1. Physical therapy: Physical therapy can help improve joint stability, reduce pain, and improve range of motion.

2. Occupational therapy: Occupational therapy can help improve daily activities and help with adaptive equipment.

3. Medications: Non-steroidal anti-inflammatory drugs (NSAIDs) can help reduce pain and inflammation.

4. Surgery: Surgery may be necessary to repair joint instability or to correct deformities.

5. Bracing: Bracing can help reduce pain and improve joint stability.

6. Splinting: Splinting can help reduce pain and improve joint stability.

7. Assistive devices: Assistive devices such as canes, walkers, and wheelchairs can help improve mobility.

8. Diet and nutrition: Eating a healthy diet and taking supplements can help improve overall

1. Genetic mutation in the COL5A1 gene
2. Family history of Ehlers-Danlos syndrome
3. Female gender
4. Joint hypermobility
5. Skin hyperextensibility
6. Fragile skin
7. Easy bruising
8. Poor wound healing
9. Early onset of varicose veins
10. Chronic musculoskeletal pain
11. Scoliosis
12. Cardiac complications
13. Gastrointestinal complications
14. Ocular complications
15. Dental complications
16. Respiratory complications
17. Autonomic nervous system dysfunction

At this time, there is no cure for Classical-like Ehlers-Danlos syndrome type 1. However, there are medications and treatments that can help manage the symptoms. These include physical therapy, pain medications, and bracing or splinting to support weakened joints. Surgery may also be recommended in some cases.